Technical Comments

Comment on “Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine”

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Science  22 Jul 2011:
Vol. 333, Issue 6041, pp. 405
DOI: 10.1126/science.1198277

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Manicassamy et al. (Reports, 13 August 2010, p. 849) deleted β-catenin in intestinal immune cells using a CD11c-driven Cre recombinase, which decreased anti-inflammatory mediators and increased inflammatory bowel disease. However, the deletion of β-catenin in macrophages remains a caveat to their interpretation that Wnt signaling programs dendritic cells into a tolerogenic state. Development of strains expressing Cre in a more finely lineage-restricted pattern may help resolve this issue.

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