Technical Comments

Response to Comment on “Activation of β-Catenin in Dendritic Cells Regulates Immunity Versus Tolerance in the Intestine”

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Science  22 Jul 2011:
Vol. 333, Issue 6041, pp. 405
DOI: 10.1126/science.1198771

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Murphy argues that deletion of β-catenin in macrophages is a caveat to our interpretation that Wnt signaling programs dendritic cells (DCs) into a tolerogenic state in the gut. However, our data demonstrate that β-catenin–deficient DCs are greatly impaired in inducing regulatory T cells, and induce enhanced T helper 17 (TH17)/TH1 responses. Assessing the relative importance of DCs versus macrophages in intestinal tolerance must await tools that permit the genetic deletion of the numerous DC and macrophage subsets in the intestine.

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