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LIFE SCIENCE TECHNOLOGIES: Protein Chemistry: Getting Above The Fold

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Science  26 Aug 2011:
Vol. 333, Issue 6046, pp. 1164-1166
DOI: 10.1126/science.333.6046.1164

Summary

Fifty years ago, biochemist Christian Anfinsen denatured some pure globular proteins, and observed that they refolded into their proper three-dimensional shapes without assistance, demonstrating that the amino acid sequence alone provides all of the information necessary to direct the folding of at least certain proteins. All researchers had to do was figure out the rules for that process, and they would be able to predict any structure from the protein's sequence.