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Science  02 Sep 2011:
Vol. 333, Issue 6047, pp. 1220
DOI: 10.1126/science.333.6047.1220-a

A Technical Comment by Postma (1) has correctly identified a problem with our 14 May 2010 Report, “Additive genetic breeding values correlate with the load of partially deleterious mutations” (2). There was an error in the methodology we developed to generate the null hypothesis against which to test the prediction that inbreeding depression correlates with breeding values in cow-pea weevils. Our mistake was to overlook the genetic relationship between predicted offspring phenotypes (p) and observed phenotypes (o). Specifically, p and o are not independent but share additive genetic variation. The null hypothesis we generated did not take this into account and hence the magnitude of the reported negative correlation between breeding values and inbreeding depression was overestimated. We reanalyzed our data with a different methodology and found a similar, but weaker, overall effect for the negative relationship between inbreeding depression and breeding values. Because the published correlation values are in error, we retract our original Report.


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