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Science  09 Sep 2011:
Vol. 333, Issue 6048, pp. 1479
DOI: 10.1126/science.333.6048.1479-a

Microtiter Plate Incubation

The SI505 is a combined incubator shaker specially designed to reduce sample evaporation and provide fast, optimized mixing of very small sample volumes in microtiter plates and microfuge tubes. The chamber of the SI505 can accommodate up to four standard microtiter or deep-well plates, or two racks holding 0.2-, 0.5-, or 1.5-ml microtubes. The high-speed orbital shaking action is ideal for effective mixing of samples in even the smallest vessels, while a state-of-the-art microprocessor enables accurate, reproducible control of temperature between ambient +7°and 60° Removable water reservoirs increase the humidity in the chamber of the SI505, minimizing sample loss due to evaporation. A retractable stainless steel platform provides easy access to samples, a digital display shows the independently controlled temperature and speed, and USB connectivity allows long-term monitoring of the incubator temperature via a PC. The outer casework of the SI505 incorporates BioCote antimicrobial technology as standard, to minimize microbial contamination.

Bioluminescent HDAC Assays

Highly sensitive bioluminescent assays are now available for measuring the relative activities of histone deacetylases (HDAC) for basic research, screening, and drug discovery. The new HDAC-Glo and SIRT-Glo Assays and Screening Systems use a single-reagent-addition, add-mix-measure protocol for easy implementation in benchtop to high throughput screening applications. The systems speed up data acquisition times and provide 10- to 100-fold higher sensitivity than comparable fluorescence assays. The HDAC-Glo Assay is broadly useful for class I and II HDAC enzymes in cells, cell extracts, or purified enzyme; the SIRT-Glo Assay is broadly useful for NAD+-dependent class III HDAC purified enzymes (Sirtuins or SIRTs). The assays use Ultra-Glo recombinant firefly luciferase technology in an add-mix-measure format in which the amount of light produced correlates to HDAC enzyme activity. The assays have broad linearity and high sensitivity, minimizing the amount of enzyme required and improving the limits of detection for screening applications.

Dual-Cooling Freezer

The extra-large capacity MDF-U700VX is an upright 728-liter, dual-cooling –86°freezer, which provides maximum sample security for valuable research or clinical samples. With two independent refrigeration systems, the freezer maintains a reliable and uniform –86°ultralow temperature environment. Should one cooling system suffer an unexpected failure, the other circuit will keep irreplaceable samples safely around –70°until service can be arranged, thus not only protecting precious samples but also preventing inconvenient and expensive out-of-hours call-outs in the event of a failure of one of the refrigeration systems. This latest dual-cooling unit offers an intelligent ECO (economy) mode, optimizing compressor operation to match the freezer's running conditions and minimize energy use. Efficient long-term operation of the freezer is facilitated by the filterless condenser design, which eliminates the need for routine filter cleaning.

Microwave Digestion System

Microwave digestion is the recognized technique for the rapid solution of difficult-to-dissolve samples. The Sineo MASTER 40 Microwave Digestion System is designed for high sample throughput under high-pressure dissolution conditions. Precise control of dissolution parameters is combined with a number of novel safety features and easy sample handling. Up to forty 70-ml dissolution vessels can be loaded into the integrated sample rotor at one time and loaded into the microwave chamber using a loading trolley that prevents direct operator contact with hot or pressurized sample vessels. 1,800 W of microwave power from two 1,000 W industrial magnetrons can generate a maximum in-vessel pressure of up to 5 MPa. Pressures up to 4 MPa can be sustained for long periods, giving the potential to digest some organic samples of up to 1.5 g in weight without pretreatment. Temperature and pressure in the vessels are continuously monitored and used to control microwave power via a rapid-feedback system.

Glycosaminoglycans Plates/Arrays

A suite of new products are designed for investigating the protein-binding properties of heparin, heparan sulfate (HS), and other glycosaminoglycans (GAGs), which have traditionally been constrained by the need for chemical modification prior to attachment to inert or derivatized surfaces. The Heparin/GAG Binding Plate offers a simple solution to this problem—the specially prepared plate surface adsorbs GAGs without modification while maintaining their protein-binding characteristics. New GAG arrays can be used to gain information on the importance of the heparin and dermatan backbone structure and the position and density of sulfate groups for protein binding. The Heparin Oligosaccharide Array can be used to determine the length of oligosaccharide required for optimum binding to a protein of interest. The K5 Polysaccharide Arrays offer a distinctive set of GAGs that contain novel sulfation motifs on N-acetylated or N-sulfated backbones.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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