PerspectiveDevelopment

Electrically Driven Insulation in the Central Nervous System

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Science  16 Sep 2011:
Vol. 333, Issue 6049, pp. 1587-1588
DOI: 10.1126/science.1212525

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  1. Insulating signals.

    Electrically active axons signal adjacent oligodendrocytes, triggering local cellular signaling pathways that promote specific myelination of active axons. Vesicular glutamate released from axons signals neighboring oligodendrocytes to form cholesterol-rich signaling domains and locally produce myelin basic protein (5).