Arranging Nucleosomes

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Science  23 Sep 2011:
Vol. 333, Issue 6050, pp. 1677
DOI: 10.1126/science.333.6050.1677-b

Nucleosomes, the core constituents of chromatin, show a stereotypical alignment with respect to transcribed genes. Specific DNA sequences have been proposed to contribute to the establishment of this pattern, yet purified histones assembled onto DNA in vitro only partially recapitulate in vivo patterns. Gkikopoulos et al. (p. 1758) show that loss of any one of a group of three chromatin remodeling enzymes had a relatively minor effect. However, removal of all three enzymes caused a dramatic loss of nucleosome organization with respect to the transcription start site and the coding regions of genes, together with a global reduction in the regular spacing of nucleosome arrays and a loss of chromatin compaction.

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