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Science  30 Sep 2011:
Vol. 333, Issue 6051, pp. 1908
DOI: 10.1126/science.333.6051.1908-a

Vacuum Pump

The Vacuubrand Vacuu•Lan Mini-Network provides distribution of vacuum from a single diaphragm vacuum pump (not included) to three vacuum ports with independent flow control. Integrated check valves isolate applications from each other to protect them from line fluctuations and resultant cross-contamination. Derived from Vacuubrand's innovative Vacuu•Lan custom laboratory vacuum installations, the Mini-Network integrates three VCL01 flow control ports into a single bar suitable for easy installation into existing laboratories. The flow path is made from fluoropolymers and other corrosion-resistant materials, making it suitable for use in most standard laboratory applications. The Mini-Network comes with installed support rods for easy mounting on laboratory support frames or stands; alternately it can be wall mounted. Vacuum can be supplied via a quiet, oil-free Vacuubrand chemistry diaphragm vacuum pump, or any other suitably sized diaphragm pump.

Colored Protein Markers

A new range of protein markers are ideal for verifying gel comparisons and monitoring electrophoresis separations. Designed to add color to comparisons and separations, CSL Pink Plus and Blue Wide Range Protein Markers can be supplied in standard and wide molecular weight ranges. Each protein marker is covalently bound to a pink or blue color chromaphore, while different colored reference bands allow easy identification during electrophoresis and after transfer. The Pink Plus option is supplied as standard 10-175 kDa with three reference bands while the Blue Wide version is supplied as 10-245 kDa with two reference bands. The protein markers, which are supplied in loading buffer for convenient and immediate use, are visible in volumes as low as 3 μL per well and are stable for two years when stored at -20°and three months at 4° 

qPCR assays

PrimeTime qPCR Assays are available in three different sizes (Mini, Standard, and XL) and provide the forward and reverse primers as well as a hydrolysis probe in a single tube. Primers and probes are also available separately, including the new Double-Quenched Probe, which increases accuracy and sensitivity through the incorporation of an internal ZEN quencher. As such, users are provided with an option to meet any experimental requirements. PrimeTime qPCR Assays allow users to select from multiple dye-quencher combinations as well as define primer:probe ratios to optimize experimental setup. Each oligo undergoes 100% QC by mass spectrometry and is shipped in two to four days of an order. PrimeTime offers Mini qPCR probes, which are ideal for gene expression screens and include a 5' FAM and the option of a 3' IBFQ quencher alone, or in combination with the internal ZEN quencher.

Bioluminescent HDAC Assays

New, highly sensitive bioluminescent assays are available for the measurement of the relative activities of histone deacetylases (HDAC) for basic research, screening, and drug discovery. The HDAC-Glo and SIRT-Glo Assays and Screening Systems use a single-reagent-addition, add-mix-measure protocol for easy implementation in benchtop to high throughput screening applications. The systems speed up data acquisition times, and provide 10- to 100-fold higher sensitivity than comparable fluorescence assays. The HDAC-Glo Assay is broadly useful for class I and II HDAC enzymes in cells, cell extracts, or purified enzyme; the SIRT-Glo Assay is broadly useful for NAD+-dependent class III HDAC purified enzymes (Sirtuins or SIRTs). The assays use the Ultra-Glo recombinant firefly luciferase technology in an add-mix-measure format where the amount of light produced correlates to HDAC enzyme activity. The assays have broad linearity and high sensitivity, minimizing the amount of enzyme required and improving the limits of detection for screening applications.

Tissue Processor

The STP 420ES Tissue Processor is designed for high throughput tissue processing. This new tissue processor enables faster turnaround times for same-day diagnosis and leaner workflows through operational flexibility. Using a dual chamber design, which features unique rotational agitation that increases flow of traditional reagents by seven-fold to reduce processing times, the STP 420ES can process up to 420 cassettes per run. Holding 360 and 60 cassettes in the first and second chambers respectively, the second chamber allows independent processing of STAT samples, as well as special or difficult tissues, without disrupting routine workflow or requiring the use of a second instrument. By performing multiple runs per day and two protocols simultaneously, a laboratory using the STP 420ES can benefit from increased processing capacity and superior agitation with no additional capital expenditure.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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