Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

Gary D. Wu; Jun Chen; Christian Hoffmann; Kyle Bittinger; Ying-Yu Chen; Sue A. Keilbaugh; Meenakshi Bewtra; Dan Knights; William A. Walters; Rob Knight; Rohini Sinha; Erin Gilroy; Kernika Gupta; Robert Baldassano; Lisa Nessel; Hongzhe Li; Frederic D. Bushman; James D. Lewis

doi:10.1126/science.1208344

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Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

Gary D. Wu¹,*,
Jun Chen²,³,
Christian Hoffmann⁴,⁵,
Kyle Bittinger⁴,
Ying-Yu Chen¹,
Sue A. Keilbaugh¹,
Meenakshi Bewtra¹,²,
Dan Knights⁶,
William A. Walters⁷,
Rob Knight⁸,⁹,
Rohini Sinha⁴,
Erin Gilroy²,
Kernika Gupta¹⁰,
Robert Baldassano¹⁰,
Lisa Nessel²,
Hongzhe Li²,³,
Frederic D. Bushman⁴,*,
James D. Lewis¹,²,³,*

¹Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
²Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
³Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁴Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
⁵Instituto de Ciências Biológicas, Universidade Federal de Goiás Goiania, GO, 74001-970, Brazil.
⁶Department of Computer Science, University of Colorado, Boulder, CO 80309, USA.
⁷Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
⁸Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.
⁹Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.
¹⁰Division of Gastroenterology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

↵*To whom correspondence should be addressed. E-mail: gdwu{at}mail.med.upenn.edu (G.D.W.); lewisjd{at}mail.med.upenn.edu (J.D.L.); bushman{at}mail.med.upenn.edu (F.D.B.)

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Science 07 Oct 2011:
Vol. 334, Issue 6052, pp. 105-108
DOI: 10.1126/science.1208344

Gary D. Wu

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: gdwu@mail.med.upenn.edulewisjd@mail.med.upenn.edubushman@mail.med.upenn.edu

Jun Chen

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Christian Hoffmann

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Instituto de Ciências Biológicas, Universidade Federal de Goiás Goiania, GO, 74001-970, Brazil.

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Kyle Bittinger

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Ying-Yu Chen

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Sue A. Keilbaugh

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Meenakshi Bewtra

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Dan Knights

Department of Computer Science, University of Colorado, Boulder, CO 80309, USA.

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William A. Walters

Department of Molecular, Cellular and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.

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Rob Knight

Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309, USA.Howard Hughes Medical Institute, University of Colorado, Boulder, CO 80309, USA.

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Rohini Sinha

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Erin Gilroy

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Kernika Gupta

Division of Gastroenterology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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Robert Baldassano

Division of Gastroenterology, Children’s Hospital of Philadelphia, Philadelphia, PA 19104, USA.

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Lisa Nessel

Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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Hongzhe Li

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Frederic D. Bushman

Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: gdwu@mail.med.upenn.edulewisjd@mail.med.upenn.edubushman@mail.med.upenn.edu

James D. Lewis

Division of Gastroenterology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.Department of Biostatistics and Epidemiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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For correspondence: gdwu@mail.med.upenn.edulewisjd@mail.med.upenn.edubushman@mail.med.upenn.edu

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Linking Long-Term Dietary Patterns with Gut Microbial Enterotypes

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