News & AnalysisCancer Research

Dispute Over Tumor Suppressor Gene Runx3 Boils Over

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Science  28 Oct 2011:
Vol. 334, Issue 6055, pp. 442-443
DOI: 10.1126/science.334.6055.442

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A key, decade-old finding by a prominent Japanese cancer researcher based at the National University of Singapore (NUS) is under fire from a group in Israel that calls it "irreproducible." If the challenge overturns the original work, which identified a gene called Runx3 as a tumor suppressor, hundreds of scientific papers might be affected. The dispute began with a scientific disagreement almost a decade ago and escalated sharply after the group in Israel filed a formal complaint earlier this fall with NUS, which recently launched an investigation.