How Proteins Fold

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Science  28 Oct 2011:
Vol. 334, Issue 6055, pp. 464-465
DOI: 10.1126/science.1214018

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Two reports in this issue probe single protein chains as they spontaneously unfold and refold. On page 517 of this issue, Lindorff-Larsen et al. (1) use state-of-the-art molecular dynamics (MD) simulations to elucidate the folding mechanisms of 12 different proteins. On page 512 of this issue, Stigler et al. (2) study the folding and unfolding of single calmodulin domains with single-molecule force spectroscopy. The results provide remarkable views of the folding process and address basic questions, such as whether proteins fold along pathways.