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Does a Gene's Location in the Nucleus Matter?

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Science  25 Nov 2011:
Vol. 334, Issue 6059, pp. 1050-1051
DOI: 10.1126/science.334.6059.1050

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Chromosomes and subnuclear bodies are not arranged randomly in the cell nucleus. How that pattern affects gene activity and other cellular functions is an enduring mystery in biology, one that won't be unraveled soon. Yet it's an important challenge. Changes in the structure within the nucleus may drive differentiation of cells. And in many diseases, including cancer, the nucleus becomes reorganized.

This article is part of the Mysteries in the Cell collection.