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Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front

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Science  25 Nov 2011:
Vol. 334, Issue 6059, pp. 1148-1150
DOI: 10.1126/science.1212880

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  • RE: Deep Human Genealogies Reveal a Selective Advantage to Be on an Expanding Wave Front

    It would be helpful to know the surnames of the early settlers. The reason is: 23andMe detected one variant (in the LRPPRC gene) of Leigh Syndrome, French Canadian Type, In my husband and also in our daughter. I quote from 23andMe website: "LSFC is a rare genetic disorder. It is characterized by life-threatening periods of lactic acid buildup and brain injury as well as failure to gain weight. A person must have two variants in the LRPPRC gene in order to have this condition." "This condition is most common in people of French Canadian descent, particularly from the Saguenay-Lac-Saint-Jean region of Quebec."

    I quote from Wikipedia):
    "Estimates of the rate of genetic carriers in the Saguenay-Lac-Saint-Jean region range from 1 in 23 to 1 in 28; the number of children born with the disease has been estimated at 1 in 2063 to 1 in 2473 live births. Genealogic studies suggest that the responsible mutation was introduced to the region by early European settlers ...

    What are surnames of the early European settlers?

    Competing Interests: None declared.