Technical Comments

Comment on “Preserved Feedforward But Impaired Top-Down Processes in the Vegetative State”

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Science  02 Dec 2011:
Vol. 334, Issue 6060, pp. 1203
DOI: 10.1126/science.1210012

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Boly et al. (Reports, 13 May 2011, p. 858) investigated cortical connectivity patterns in patients suffering from a disorder of consciousness, using electroencephalography in an auditory oddball paradigm. We point to several inconsistencies in their data, including a failure to replicate the classical mismatch negativity. Data quality, source reconstruction, and statistics would need to be improved to support their conclusions.

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