Autophagy in Tumor Immunity

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Science  16 Dec 2011:
Vol. 334, Issue 6062, pp. 1501-1502
DOI: 10.1126/science.1216428

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Autophagy can promote the survival of tumor cells through nutrients recovered from degrading and recycling damaged organelles. How this mechanism can stimulate or limit the immune system's attack on tumor cells has not been well understood (1). On page 1573 of this issue, Michaud et al. (2) show that in mice, chemotherapy-induced autophagy causes the release of adenosine 5′-triphosphate (ATP) from tumor cells, thereby stimulating antitumor immune responses.

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