PerspectiveMolecular Biology

Translation Goes Global

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Science  16 Dec 2011:
Vol. 334, Issue 6062, pp. 1509-1510
DOI: 10.1126/science.1216974

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Global information about the extent of proteins being synthesized in a given cell has lagged behind our knowledge of genomic sequence information and RNAs. Now, a recent study highlights the extent to which this deficit is being rectified (1). Ingolia et al. expand the use of a technique they call ribosome profiling (2) to take “snapshots” of the complexity of mammalian proteomes—the constellation of proteins present in a cell or one of its compartments—focusing on messenger RNAs (mRNAs) being actively decoded to synthesize protein products and revealing several surprises.