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Science  13 Jan 2012:
Vol. 335, Issue 6065, pp. 239
DOI: 10.1126/science.335.6065.239-a

High-Speed Fluorescence Imaging Camera

The Rolera Bolt Scientific CMOS camera is a high-speed imaging alternative that is less than half the cost of most scientific complementary metal oxide semiconductor (CMOS) and charge-coupled device (CCD) cameras. Designed for low-light imaging, the Rolera Bolt is especially suited for biomedical imaging as more research moves toward live-cell and whole-organism studies at video frame rates. This includes motility studies in which dynamic events need to be captured with high spatial and temporal resolution in order to provide the maximum amount of information to the researcher. The camera's technical features include a high quantum efficiency 1.3 megapixel sensor (3.63 μm ×3.63 μm pixel size) combined with low read noise (~3e) and high-speed (30 frames per second full resolution) simultaneous readout. Using new Pixel-Freeze Technology, dark current is reduced to nearly undetectable levels, eliminating the need for an expensive Peltier cooling system. This allows for a lightweight, compact design with minimal power requirements.

High Content Screening System

Incorporating state-of-the-art detector and illumination technologies, the ImageXpress Micro XL System can capture cellular resolution images using a single field that encompasses one 384 well, maximizing content up to twofold of what is acquired with standard camera HCS systems. This generous increase in field of view allows users to image twice the number of objects per image, minimizing the need to tile when capturing sizeable objects that span across the sample. The new MetaXpress 4 Software complements the ImageXpress Micro XL System by increasing image analysis speed 100%, allowing acquisition and analysis of greater than 10 million cells per hour. Maintaining extensive sample and objective compatibility, combined with the longevity of a 10,000+ hour light source, the ImageXpress Micro XL System offers researchers an extremely flexible widefield high content screening system that can grow with expanding applications.

Acoustic Biosensor

The samX acoustic biosensor features eight analysis channels and adaptable routing that expands the workflow options available for increased power and flexibility. The new system uses Surface Acoustic Wave technology to detect mass binding and protein conformational changes on whole cells. Unlike many similar detection platforms, the range of sam acoustic biosensors do not require complex labelling methods, are real-time rather than equilibrium, and can be used to investigate living cells rather than fixed cells or purified proteins. The new samX has two sensor chips for higher-end users, increasing the number of channels to eight, further facilitating the parallel processing of samples. Using sophisticated fluidics, each channel can be utilized independently or via sequential combinations of 4 x 2, 2 x 4, or 1 x 8 channels. This optimizes user workflow, regardless of whether discrete or common reagents need to be delivered to particular sensor chip positions.

DNA Barcodes

The NEXTflex-96 DNA Barcodes reduce the costs associated with next generation sequencing by increasing throughput using barcoded indices. This allows the user to pool multiple library preparations in a single flow cell lane. The NEXTflex-96 DNA Barcodes accomplish this by providing 96 indexed adapters, each of which contains a unique eight-nucleotide sequence. The indices are designed to be error resistant and allowing for proper differentiation between samples. Using the NEXTflex-96 DNA Barcodes, the index is added to the sample during the adapter ligation step, allowing polymerase chain reaction (PCR) amplification to be reduced or eliminated, thus minimizing amplification-based bias and preventing poor reads from single base errors introduced during PCR. These barcodes can be used to multiplex genomic DNA, RNA, and ChIP sequencing libraries.

Electronic Microplate Sealer

Designed for convenience, the compact MiniSeal only requires plugging into a single electrical outlet to operate. This eliminates the need to place your thermal sealer near a compressed air source or buy a dedicated compressor. Unlike hand-operated manual thermal sealers, the MiniSeal uses a preset sealing pressure to deliver highly reproducible plate seals time after time. To complement its ease of use and high-quality plate sealing, the MiniSeal ensures operator safety with its unique twin-button operation. The MiniSeal offers researchers a reliable and productive sealing tool for maintaining the integrity of their samples while in storage. The versatile device is capable of producing an accurate and tight seal on any standard, deep-well, or polymerase chain reaction (PCR) microplate from 3 to 62 mm in height. Offering adjustable temperature heat-sealing from 50°C up to 200°C, MiniSeal is able to operate optimally with most foil and film seals.

Steroid/Drug/Compound Immobilization Kit

The SDC (Steroid/Drug/Compound) Immobilization Kit generates affinity resins by immobilizing steroids, drugs, and other chemical compounds. Immobilization is preformed through active hydrogens, eliminating the need for primary amines, sulfhydryls, carbonyls, and other common coupling groups. The coupling uses the Mannich reaction, described as the condensation of formaldehyde with ammonia in the form of its salt, and another compound containing active hydrogen. The SDC Immobilization kit replaces the ammonia with the primary amine on the DADPA and the active hydrogen is supplied by the steroid, drug, or chemical compound to be coupled. The SDC Immobilization Kit is ideal for the generation of five 2 mL affinity columns.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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