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Nanoscopy in a Living Mouse Brain

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Science  03 Feb 2012:
Vol. 335, Issue 6068, pp. 551
DOI: 10.1126/science.1215369

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Abstract

We demonstrated superresolution optical microscopy in a living higher animal. Stimulated emission depletion (STED) fluorescence nanoscopy reveals neurons in the cerebral cortex of a mouse with <70-nanometer resolution. Dendritic spines and their subtle changes can be observed at their relevant scales over extended periods of time.

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