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Science  03 Feb 2012:
Vol. 335, Issue 6068, pp. 605
DOI: 10.1126/science.335.6068.605-a

Stackable Desiccators

Multi-Storey Cubic Desiccators overcome the space inefficiencies of traditional round desiccators which occupy a large bench area while providing only a small circular shelf for actual sample placement. This range of desiccators comprises four multi-shelved stackable cubic desiccators, which are made from highly transparent, noncorrosive, and shatterproof polycarbonate. The internal volumes range from 11 to 45 L with between two and six shelves, and this significantly enhances the storage capacity of the desiccators. Each unit has a full front door that uses a grease-free airtight vacuum seal, which ensures that a vacuum of 1 Torr over 72 hours is held. Also, a vacuum gauge is mounted on the top left hand side of the door while the three-way stopcock mounted on the left hand side of the chamber allows for the removal and replacement of the internal atmosphere as needed. Each unit is available in smoked acrylic to block ultraviolet light.

Inverted Light Microscope

The Axio Vert.A1 is an inverted microscope with extensive performance capabilities. For the first time, a compact cell culture microscope combines all standard contrasting techniques in a single stand. In transmitted light, the Axio Vert.A1 offers brightfield, phase contrast, polarization contrast, PlasDIC, VAREL, and improved Hoffmann modulation contrast (iHMC). The microscope is the only system in its class to also offer differential interference contrast (DIC). This makes it possible to record very fine structures in cells, enabling users to better assess cell cultures. In fluorescence applications, the Axio Vert.A1 uses long-life LED illumination. The entire image field is illuminated homogeneously; no alignment is necessary. As LED excitation light does not contain any undesired ultraviolet components, cell survival rate increases significantly. The Axio Vert.A1 has been specially designed so that it can be positioned directly beside the incubator or the sterile bench. Adapters allow comfortable, upright work in either a seated or standing position.

PARP1 Enzyme Activity Assay

The PARP1 Enzyme Assay is designed for detection of poly (ADP-ribose) polymerase (PARP) activity and screening of activators and inhibitors. PARPs catalyze the addition of ADP-ribose moieties onto substrate proteins and play a role in DNA repair, chromatin structure, cell cycle, and cell death. The kit is a flexible, homogenous, no-wash assay for quantifying enzymatic activity. Based on patent-pending technology, this assay employs nicotinamidase to measure nicotinamide generated upon cleavage of NAD+ during PARP-mediated poly-ADP-ribosylation of a substrate, thereby providing a direct, positive signal assessment of the activity of PARP1 and PARP2. The new PARP assay utilizes a novel, patent-pending fluorescently coupled enzyme assay for nicotinamide degradation to permit the use of native NAD+ substrate and flexibility with peptide/protein acceptor substrates.

Antibody Array

The Panorama Neurobiology Antibody Array is designed for fast protein expression analysis of hundreds of signaling targets that are indicative of neuronal health and development. The Panorama Neurobiology Antibody Array assesses a broader range of signaling targets, and is expected to provide the most comprehensive view available of the cell signaling and regulation pathways that are key to neuronal development and neurodegenerative disorders. The Panorama Neurobiology Antibody Array enables, within a single day, direct comparisons of neuronal protein expression patterns using a variety of serum, cell, or tissue extracts derived from humans, mice, or rats. The array's 224 polyclonal and monoclonal antibodies are spotted in duplicate, high-density spots on a nitrocellulose-coated slide treated to reduce background fluorescence. Antibodies in the array are also available separately from the Sigma Life Science Antibody catalog of more than 50,000 antibodies.

BioSpectrometer

The new Eppendorf BioSpectrometer combines accuracy and sensitivity with outstanding flexibility in a small robust instrument. The Eppendorf BioSpectrometer extends our current detection product line by offering scanning capabilities allowing routine and complex methods such as measuring cytotoxicity, proteins, fluorescent dyes, and more. The BioSpectrometer kinetic model features a temperature-controlled cuvette shaft that requires no additional accessories in order to study enzyme or substrate kinetics. Scanning spectrum as well as individual wavelength measurements can be monitored in the spectral range of 200 to 830 nm. Preprogrammed methods facilitate quick start applications and prevent errors, while a USB port is provided for simple data transfer. No PC is necessary to operate the system and integrated data processing options enable basic data processing directly on the device. Apart from standard cuvettes such as the Eppendorf UVette, the BioSpectrometer can also accommodate micro volume cuvettes.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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