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LIFE SCIENCE TECHNOLOGIES: A New Era For Clinical Models

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Science  24 Feb 2012:
Vol. 335, Issue 6071, pp. 994-996
DOI: 10.1126/science.335.6071.994

Summary

Not long ago, a clinically relevant and genomics-based model of disease meant an animal, but today's models also include cell lines and even computer-based simulations. Still, bioengineered mice and rats make up many of the models, and these genetically modified organisms provide increasingly accurate representations of how drugs treat human diseases. To get the most from genomics-based models for drug research, scientists can now combine information from bioengineered organisms, genomically modified cell lines, and computational models.

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