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Science  02 Mar 2012:
Vol. 335, Issue 6072, pp. 1126
DOI: 10.1126/science.335.6072.1126-a

CELL ANALYZER

The innovative Muse Cell Analyzer system can be used for real-time quantitative assessment of cell concentration, cell health, apoptosis, and cell cycle with greater accuracy and precision than manual hemocytometry or image-based automated analysis. By providing real-time, multidimensional information on cell populations, the Muse cell analyzer enables faster, more accurate decision-making, more productive workflows, and greater insight into cell health. The Muse system delivers high performance cell analysis using miniaturized fluorescent detection and microcapillary technology, which occupy one-tenth the space of a typical cytometer. Laser-based fluorescence detection of each cell event can evaluate up to three cellular parameters. As a result, Muse provides accurate quantitative results compared to imaging-based systems, which only examine up to two parameters, are time-consuming, and ultimately provide less quantitative data. The system is capable of analyzing both suspension and adherent cells from 2 to 60 μm in diameter. Intuitive software and simple touchscreen interface enable rapid setup and analysis.

ENDOCRINE-ACTIVE CHEMICALS TEST

The ToxInsight Endocrine Profiler Panel (EPP) is a groundbreaking new tool for assessing the risk of human exposure to endocrine-active chemicals in the environment. EPP cartridges measure estrogen and androgen receptor activity in human cell lines. Each cartridge includes all the cell lines, reagents, assay protocols, growth media, plasticware, analysis, and data-reporting capabilities to profile compounds for endocrine activity with high sensitivity and specificity. EPP cartridges, coupled to the ToxInsight CHPS platform, offer a high throughput, quantitative prescreen for primary toxicology assessment, as well as a selection of chemicals for follow-up animal studies, in a simple mix-and-read format that is easily standardized. This automated, benchtop platform is easy-to-use and provides physiologically relevant toxicity assays in vitro, reducing the reliance on late-stage histopathology or animal studies. The ToxInsight CHPS platform not only profiles compounds for their toxicity risk, but also determines the mechanism of action of any toxicity detected.

IMAGE DATA STORAGE AND ANALYSIS

Researchers in the areas of cancer and stem cells, predictive toxicity, neuroscience, and developmental biology can benefit from the improved capabilities of the updated Columbus 2.3 Image Data Storage and Analysis System, which are intended to enable faster and more powerful high content analysis-based research applications. The Columbus 2.3 platform now enables scientists to perform their high content analysis on one powerful platform, from image analysis through to secondary analysis, regardless of which high content screening (HCS) instrument they have. The secondary analysis capabilities can enable scientists to select small interfering RNA (siRNA) or compounds with desirable inhibition or activation effects, by proving the statistical significance of the observations made at the image analysis stage of a HCS campaign. Multiple plates or batches are analyzed, filtering out anomalies, and identifying trends. The software's improved morphology analysis capability is designed to give scientists a more complete understanding of the effects different treatments have on cell samples.

MICROBIAL COLONY PICKERS

The QPix 400 series, the next generation of microbial colony pickers, offers unmatched performance and productivity enabling scientists to manage large, diverse populations, including 98% efficiency in colony picking, far surpassing the industry standard. The QPix 400 series features the unique option to simultaneously detect colonies and quantify fluorescent markers. This prescreening step enables the colonies of interest to be objectively identified and selected. Together with highly accurate robotics and organism-specific colony picking pins, scientists can ensure that the right colony is picked every time, thus eliminating unnecessary work and expense downstream. An agar height sensor further increases accuracy at the picking stage. Application-driven software includes tools to easily track sample histories throughout a workflow. Applications include areas such as protein expression, biofuel research, enzyme evolution, phage display, DNA sequencing, and library generation and management.

APOPTOTIC BODY DNA ANALYSIS

The D-Pop Kit simplifies the capture of DNA-containing particles from cell-free biological samples such as blood serum and plasma, urine, and eukaryotic cell culture media as well as the extraction of DNA from the captured particles. Using the D-Pop Kit, apoptotic bodies and potentially other large particles are captured from biological fluids in minutes by passing them through a filter in a syringe format. The filter is then removed to a microfuge tube and the DNA is extracted from it using a rapid solid-phase extraction of DNA with nonorganic reagents. The D-Pop Kit also includes control polymerase chain reaction primers for the hTERT gene to verify concentration and recovery of DNA from the sample.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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