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Science  09 Mar 2012:
Vol. 335, Issue 6073, pp. 1243
DOI: 10.1126/science.335.6073.1243-a


BiOS is an automated system designed for ultralow temperature storage of sensitive biological samples. This flexible, scalable system ensures the integrity of 250,000 to more than 10 million sample tubes at temperatures down to -85° All samples within the BiOS are stored in -85°chest freezer compartments to maintain temperature stability. All internal workflows, including sample picking, are optimized to keep samples at ultralow temperatures at all times. System parts are easily accessible for service and maintenance. One- and two-dimensional barcode reading and sample tracking produce complete chain-of-custody documentation, with software tools to support 21 CFR Part 11 compliance. Multiple redundant backup systems ensure the samples stay at -85° even in emergencies. The BiOS can store and process multiple labware types in the same system.


The High Capacity Endotoxin Removal Resin is designed for the cleanup of protein that is injected or transfected into cells or animals. The Pierce High Capacity Endotoxin Removal Resin combines porous cellulose beads and an FDA-approved food preservative, poly (ε-lysine), as an affinity ligand to selectively bind endotoxins. Endotoxin levels in protein samples are reduced by greater than 99% in as little as one hour using a spin cup format, and protein recovery is greater than 85%. The Pierce High Capacity Endotoxin Removal Resin peptides have a high affinity for the charged glycol-groups of an endotoxin, while the particle pores help trap endotoxins. The modified polylysine affinity ligand eliminates the toxicity concerns associated with alternative technologies that use polymixin B ligands and sodium deoxycholate buffers. The Pierce High Capacity Endotoxin Removal Resin is available in either bulk slurry packages for researchers who want to pack their own columns or convenient, single-use, spin-column formats.


The NZ400 NanoScan Piezo Stage System is well suited for researchers producing rapid Z sections and live cell 3-D images of specimens grown in well plates, large petri dishes, or mounted to glass slides. With the ability to create a stack of images using multiple objectives in the z-axis with nanometer precision at an amazingly high speed, the NanoScan is the perfect accessory for any 3-D imaging application. The NZ400 NanoScan Piezo Stage System offers 400 μm of travel, 2.5 nm repeatability, and closed loop control utilizing a subangstrom resolution piezo resistive sensor. Designed to mount to the Prior ProScan H117 series of high precision motorized stages, the NZ400 can also be provided as a standalone device that can be mounted onto a wide range of XY stages. Compatible with most leading imaging software packages, the NZ400 comes standard with control inputs for RS232, USB, and 0—10 V analog input.


The D-Pop Kit simplifies the capture of DNA-containing particles from cell-free biological samples such as blood serum and plasma, urine, and eukaryotic cell culture media, and the extraction of DNA from the captured particles. Using the D-Pop Kit, apoptotic bodies and potentially other large particles are captured from biological fluids in minutes by passing them through a filter in a syringe format. The filter is then removed to a microfuge tube and the DNA is extracted from it using a rapid solid-phase extraction of DNA with nonorganic reagents. The D-Pop Kit also includes control polymerase chain reaction primers for the hTERT gene to verify concentration and recovery of DNA from the sample.


A new high quality, inexpensive ultraviolet crosslinker makes it possible to identify and analyze trace amounts of DNA/RNA with far greater sensitivity, accuracy, and speed than with conventional analysis. The Select XLE-Series UV crosslinker covalently binds nucleic acids to membranes in less than 30 seconds—240 times faster than vacuum-oven baking. It has a unique true-ultraviolet (UV)-monitoring circuitry that safeguards valuable test results from washouts, even when the tubes age. Researchers also rely on this versatile instrument for eliminating polymerase chain reaction (PCR) contamination, nicking ethidium-bromide-stained DNA in agarose gels, gene mapping for creating cleavage-inhibiting thymine dimers, RecA mutation screening in E. coli, UV sterilization, and miscellaneous UV-dosage applications. The Select Series crosslinker features a "smart" user-friendly, fully programmable microprocessor, built-in "help" messages and an auto-repeat function that make its operation amazingly fast and simple. It features five 8 W tubes and is available in a choice of 254 nm, 312 nm, and 365 nm versions.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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