Technical Comments

Comment on “Widespread RNA and DNA Sequence Differences in the Human Transcriptome”

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Science  16 Mar 2012:
Vol. 335, Issue 6074, pp. 1302
DOI: 10.1126/science.1210624

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Abstract

Li et al. (Research Articles, 1 July 2011, p. 53; published online 19 May 2011) reported widespread differences between the RNA and DNA sequences of the same human cells, including all 12 possible mismatch types. Before accepting such a fundamental claim, a deeper analysis of the sequencing data is required to discern true differences between RNA and DNA from potential artifacts.

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