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Long-Range–Projecting GABAergic Neurons Modulate Inhibition in Hippocampus and Entorhinal Cortex

Science  23 Mar 2012:
Vol. 335, Issue 6075, pp. 1506-1510
DOI: 10.1126/science.1217139

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Abstract

The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid–releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.

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