PerspectiveMedicine

Irisin, Light My Fire

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Science  06 Apr 2012:
Vol. 336, Issue 6077, pp. 42-43
DOI: 10.1126/science.1221688

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Summary

Regular physical activity confers enormous fitness benefits. Exercise training enhances muscular endurance and strength, expends calories, and combats the development of common diseases such as obesity and type 2 diabetes. The effects of exercise are systemic and seemingly cannot be explained solely by the expenditure of calories in muscle (1). A recent study by Böstrom et al. (2) describes a mechanism that may elucidate how total body energy expenditure is increased by exercising muscle.