News FocusTHE BIOLOGY OF GENOMES

HDL Itself Does Not Prevent Heart Attacks

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Science  25 May 2012:
Vol. 336, Issue 6084, pp. 977
DOI: 10.1126/science.336.6084.977

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Summary

If you are hoping to lower your risk of a heart attack simply by raising your levels of "good" cholesterol—high-density lipoproteins (HDLs)—you may be disappointed. Although epidemiological studies point to HDLs as protective against heart disease, a new genetic analysis presented at the meeting shows that while high HDL might correlate with a healthier heart, it's not itself responsible for lowering heart attack risks.