Systems Biology, Metabolomics, and Cancer Metabolism

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Science  25 May 2012:
Vol. 336, Issue 6084, pp. 990-991
DOI: 10.1126/science.1223066

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Recent breakthroughs in cancer metabolism include the identification of an alternative glycolytic pathway in proliferative cells (1) and an essential role for the serine synthesis pathway in breast cancer (2). With a data-driven approach, as opposed to the conventional hypothesis-driven approach, in this issue, on page 1040, Jain et al. (3) determined that rapidly proliferating cancer cells require large amounts of the nonessential amino acid glycine, which has clear and direct implications for cancer therapy.