When Less Signaling Is More

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Science  01 Jun 2012:
Vol. 336, Issue 6085, pp. 1120-1121
DOI: 10.1126/science.1223811

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A crowded party means lots of sensory inputs and the need to “tune out” distracting signals to have productive interactions. On page 1178 in this issue, Khalil et al. (1) suggest that in a crowded environment, B cells too must tune out distracting inputs so that they can be responsive to key interactions.