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Structure of a 16-nm Cage Designed by Using Protein Oligomers

Science  01 Jun 2012:
Vol. 336, Issue 6085, pp. 1129
DOI: 10.1126/science.1219351

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Abstract

Designing protein molecules that will assemble into various kinds of ordered materials represents an important challenge in nanotechnology. We report the crystal structure of a 12-subunit protein cage that self-assembles by design to form a tetrahedral structure roughly 16 nanometers in diameter. The strategy of fusing together oligomeric protein domains can be generalized to produce other kinds of cages or extended materials.

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