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Science  01 Jun 2012:
Vol. 336, Issue 6085, pp. 1186
DOI: 10.1126/science.336.6085.1186-a

COLONY COUNT/ZONE MEASUREMENT SYSTEM

The ProtoCOL 3 is an affordable colony counting and zone measurement system. Designed for flexibility and accuracy, the system can read plates of 30–150 mm, detecting colonies as small as 43 μm and measuring zones to 0.1 mm, tasks that no other automated colony counter can achieve. Additionally, the ProtoCOL 3 system's unique tri-color imaging method means performing challenging applications such as distinguishing grid lines on filters from colonies and counting black colonies on dark media are made quick and easy. The system comes complete with software for basic colony counts and zone measurements. IQ, OQ, and PQ documentation is also available to allow the system to be integrated into a GMP environment. ProtoCOL 3 can be supplied with a computer or users can utilize their own and simply install the ProtoCOL 3 software.

CELL LINE DEVELOPMENT

The new Cell Metric CLD benchtop system is optimized to provide fast, reliable, and automated cell line development (CLD). The high resolution offered by the unique cell imaging and analysis system offers an alternative approach to manually checking cell line monoclonality, providing the fast, unequivocal identification, qualification, and tracking of clones derived from single cells. The proven Cell Metric platform is paired with an integrated stacker system to form the new Cell Metric CLD. Using high resolution imaging that offers three times as many pixels as previous generation cell imaging instruments, the Cell Metric CLD system generates clear images of cells taken soon after seeding or sorting, providing confidence that a colony has grown from a single cell. The system also benefits from an automatic focus, ensuring that images are clear, consistent, and informative.

CELL CULTURE SYSTEM

The new RAFT (Real Architecture for 3-D Tissue) System generates consistent and reproducible 3-D cell cultures at physiologically relevant collagen concentrations, ideal for oncology and stem cell research. The new RAFT includes a simple three-step process of mix, make, and measure, simplifying the route to improved results from 3-D experiments. Scientists simply mix the reagents from the kit with their cells, pipette into 96-well plates, and incubate on the plate heater for 30 minutes to form a cell-seeded collagen hydrogel. The RAFT plate is placed on the hydrogels, and in just 15 minutes the medium is absorbed gently, leaving cells "encapsulated" in physiological strength collagen, perfect for use in their cell-based assays. Using the RAFT system helps to create a realistic cellular environment to study cells' complex behavior and gives scientists complete control over their experimental parameters, including choice of cell types and cell seeding densities.

3-D PROLIFERATION ASSAYS

A new range of 3-D proliferation assays make downstream applications of 3-D cell culture easier. Cultrex Cell Proliferation Assays were created in an effort to provide more physiologically relevant assessments when using cell models in the screening process for compounds that influence toxicity, cell survival, tumorigenicity, and new tumor formation. These proprietary assays offer a flexible, standardized, high throughput format for quantitating the degree to which pharmacological compounds influence toxicity or tumorigenicity in an in vivo-like environment. The Cell Proliferation Assay methodology has been adapted to multiple formats so that cell proliferation may be evaluated against different extracellular matrices. The assay is available for 3-D growth in Basement Membrane Extract (BME), Laminin I, and Collagen I formats.

HIGH CONTENT ANALYSIS PLATFORM

The ArrayScan Infinity HCS Reader with 3-D imaging capability is specifically designed to enhance high content analysis for stem cell and oncology research. The ArrayScan Infinity HCS Reader features the latest in spinning-disk confocal technology, solid-state LED illumination, and live-cell and label-free capabilities as well as best-in-class image analysis and bioinformatics software. The high-speed Nipkow spinning disk and multiple pinholes give more resolution options compared with traditional confocal technology. In addition, multimode wide-field and confocal imaging offers a balance of image quality and performance that is ideal for tissues and complex morphologies. Finally, the confocal module on the ArrayScan Infinity HCS Reader has a four-color LED Light Engine, bringing robust, laser-like performance without the complications and cost of lasers or the poor performance of lamp-based technology. The ArrayScan Infinity HCS Reader, with its assay development oriented software, enables complex 3-D structures to be imaged more clearly, yielding more detailed quantitative information.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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