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Crystal Structure of Human Enterovirus 71

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Science  08 Jun 2012:
Vol. 336, Issue 6086, pp. 1274
DOI: 10.1126/science.1218713

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Abstract

Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the “pocket factor,” a small molecule that stabilizes the virus, is partly exposed on the floor of the “canyon.” Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.

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