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Science  06 Jul 2012:
Vol. 337, Issue 6090, pp. 115
DOI: 10.1126/science.337.6090.115-a

CONFOCAL PLATFORM

Combining high-performance optics, the fastest true confocal scanner, and the most sensitive detection system available, the Leica TCS SP8 is a single platform that can be upgraded to serve a wide range of imaging applications. Superresolution and supersensitivity imaging, single-molecule detection, CARS microscopy, high-content screening, electrophysiology, and deep-tissue imaging with more than one multiphoton source are all within the scope of the Leica TCS SP8—and are available as options that can be added on as the researcher's needs change. At the heart of the optical core, Leica's scanner options can be configured for resolution, speed, or field of view without compromise. Scanning speeds of 428 frames per second can be reached with the new 12 kHz Tandem Scanner, while the Field of View (FOV) scanner offers the largest available field of view.

PROTEIN NANOARRAY

The NanoInk multiplexed NanoArray automated system enables detection, identification, and quantitation of clinically relevant, low abundance proteins from a wide variety of sample types. NanoInk assays consume much smaller sample and reagent volumes than traditional enzyme-linked immunosorbent assay and bead-based assays, generating more proteomic data with less starting material and lowering assay costs. NanoInk's assays provide customers the choice of automated proteomic analysis or simple benchtop testing using standard immunoassay protocols. The automated format combines a small sample size advantage with the additional benefit of high throughput precision and speed. The latest NanoInk assay kits include all protocols, reagents, and SBS compliant consumables needed to conduct NanoArray studies on commercially available lab automation systems. Additionally, NanoInk array slides are compatible with 96- and 384-well sample microplates. Whether using the automated or manual assay format, NanoInk's miniaturized immunoassay platform can extract multiplexed protein biomarker data from just 2 μL of sample.

OLIGONUCLEOTIDE SYNTHESIS

For triplex, antisense, and gene targeting studies, the new RNA-type phosphoramidites provide nuclease resistance and stability, while the new ethyl phosphoramidites improve oligonucleotide stability and delivery into cells, making them ideal for therapeutic applications. Building on from the existing range of standard nucleobase RNA phosphoramidites and CPG supports, the modified RNA-type phosphoramidites comprise two new 2'-OMe RNA products, 2'-OMe-I and 2'-OMe-T. Oligonucleotides containing these modifications are ideal for triplex, antisense, and gene-targeting studies, as they form more stable hybrids with complementary RNA strands compared to equivalent DNA or RNA strands. Furthermore, when used in gene targeting studies, the addition of 2'-OMe residues into triplex forming oligonucleotides, confers the same nuclease resistance and stability as seen with duplexes. Oligonucleotides synthesized from these new ethyl phosphoramidites have a neutral charge and slightly lipophilic character, which improves their delivery into the cell.

PARTICLE SIZE DISTRIBUTION ANALYSIS

A material's particle size distribution can have a major impact on the desired characteristics and performance of a final product. The new SALD-2300 laser diffraction particle size analyzer measures wet or dry materials to ensure outstanding product quality for the pharmaceutical, food and beverage, ceramics, and electronics industries. The SALD-2300 provides continuous measurement in real time, at minimum one-second intervals. Its measurement range spans particle sizes from 17 nm to 2,500 μm, and users can select various sample amounts depending on measurement objectives. The instrument's Wing Sensor II achieves high-resolution particle detection with its 78 concentric detector elements. In addition to the Wing Sensor II, one sensor detects side-scattered light, and five other sensors are used for back-scattered light. The SALD-2300 comes with WingSALD II software, which automatically calculates an appropriate refractive index based on the light intensity distribution reproduction method. This function eliminates the challenges associated with selecting refractive indices.

UHPLC SYSTEM

The new nano-Advance Ultra High Performance Liquid Chromatography (UHPLC) system, for capillary and nano-flow LC-MS applications, delivers reproducible retention times with accurate gradients down to 50 nL/min. With run-to-run sample carryover typically less than 0.005%, the nano-Advance UHPLC delivers industry-leading separation performance critical to the success of many proteomics workflows. The nano-Advance UHPLC was specifically designed to eliminate dead volume and gradient delay wherever possible. When combined with Bruker's unique CaptiveSpray Ion source, the combination can deliver up to twice the MS utilization rate of typical nano-LC systems coupled to nanospray MS sources. The increased mass spectrometry utilization rate enables more proteins and peptides to be identified and quantified in a single LC-MS run. The nano-Advance UHPLC delivers precise nanoliter-scale flow rates without the need for any split-flow due to the incorporation of two high-performance direct drive syringe pumps. There is also a third pump for trap loading and 2-D LC applications.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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