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Science  27 Jul 2012:
Vol. 337, Issue 6093, pp. 488
DOI: 10.1126/science.337.6093.488-a

LOW-TEMPERATURE COOLERS

A line of low temperature coolers provide rapid, low-cost cooling of liquids to temperatures as low as -100° Available in both immersion probe and flow through styles, these compact systems are ideal for cooling exothermic reactions, freeze point determinations, freeze drying, impact testing, lyphilization, and vapor and solvent trapping. Excellent for trapping, Dewar-type applications, and the rapid cool down of small volumes of liquids, PolyScience Immersion Probe Style Coolers reduce the expense of using dry ice or liquid nitrogen and are capable of reaching temperatures as low as -100° A flexible hose allows convenient placement of the cooling probe. Seven different models as well as a variety of probe types are available. Capable of reaching temperatures as low as -25° PolyScience Flow-Through Style Coolers are ideal for extending the temperature range of nonrefrigerated circulators to below ambient as well as boosting the cooling capacity of refrigerated circulators.

IN VITRO TRANSLATION SYSTEM

1-Step Human High Yield In Vitro Translation (IVT) Kits have a continuous-feed device and can produce 10- to 100-times more functional protein per milliliter than other eukaryotic IVT systems. The protein obtained with the 1-Step Human High Yield IVT Kit can be used for structural analysis, antibody production, and kinetic or enzymatic assays. The kit uses modified HeLa cell extracts to provide the protein expression machinery. Protein expression is performed using a proprietary mini-dialysis device that allows the continuous supply of nucleotides, amino acids, and energy-generating substrates to extend the protein translation reaction. The device also allows the removal of protein synthesis inhibitors. With the kit, protein expression can continue for up to 24 hours, providing protein yields ranging from 250 to 750 μg per milliliter. The complete 1-Step High Yield IVT Kits supply all components necessary for the transcription and translation of protein, including an optimized expression vector, pT7CFE1-CGST-HA-His.

IMAGE CYTOMETRY SYSTEM

The Cytell Image Cytometer is a benchtop-sized image cytometer for rapid cell characterization that introduces researchers to a new, simpler, faster, and more productive way to conduct their cell analysis. The new Cytell Image Cytometer enables researchers to capture detailed data about their cells quickly while using minimal sample volumes. Data can be acquired for up to eight samples at a time and results are delivered through an intuitive graphical interface in less than two-and-a-half minutes. The system simplifies researchers' working practices and increases productivity by removing the need to use specialized cell analysis instruments. Large cell analysis instruments are often in a shared facility, which can be difficult to access at the right time and time-consuming to use.

TISSUE-SPECIFIC CONDITIONAL KNOCKOUT

CompoZr Zinc Finger Nuclease (ZFN) technology has been extended to achieve the first tissue-specific conditional knockout of an endogenous gene in rats. Rats engineered to contain tissue-specific conditional gene knockouts are available exclusively through the SAGEspeed Custom Model Development Service. Conventional gene knockout eliminates a gene throughout an entire animal. In contrast, conditional gene knockout can eliminate a gene solely in the relevant tissue or organ, leading to a more accurate understanding of the gene's function. Conditional gene knockout can also knockout genes at certain points in development, enabling studies of genes whose absence in embryos is lethal, but whose loss of function in adulthood is critical to investigate for many human diseases. CompoZr ZFN technology is the first to enable highly efficient, targeted editing of the genome of any species.

DIGITAL HOLOGRAPHIC PHOTOMANIPULATION

The first commercial implementation of a phase-only spatial light modulator (SLM) designed specifically for patterned and 3-D point photomanipulation in optical microscopy. It is a compact, modular device that couples to a microscope documentation port and the 3i LaserStack laser launch. Phasor can be used for optogenetic stimulation, uncaging, and other types of photomanipulation. One major advantage of its technology over older methods is that a significant portion of laser intensity can be simultaneously redirected to just those regions where photomanipulation is desired, rather than being either sequentially scanned or mostly blocked. In optical stimulation of brain slices, for instance, action potentials can be elicited at multiple locations in parallel with less than one millisecond of laser illumination. Region specification, hologram generation, and experimentally synchronized optical path switching and laser illumination gating are managed within 3i's SlideBook software.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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