PerspectiveCell Biology

Precursor or Charge Supplier?

Science  10 Aug 2012:
Vol. 337, Issue 6095, pp. 653-654
DOI: 10.1126/science.1227096

You are currently viewing the summary.

View Full Text

Summary

Phosphorylated derivatives of phosphatidylinositol (PI) play critical roles in cell signaling and in regulating membrane traffic and cytoskeletal architecture (1). Phosphatidylinositol 4-phosphate (PI4P), for instance, is essential to the formation of vesicular carriers in the trans-Golgi network (2), and serves as a substrate for the synthesis of phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P2] in the plasma membrane. On page 727 of this issue, Hammond et al. (3) reveal an unappreciated function of plasmalemmal PI4P in controlling protein recruitment and ion channel activity.