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Science  31 Aug 2012:
Vol. 337, Issue 6098, pp. 1123
DOI: 10.1126/science.337.6098.1123-a


The CoolSNAP MYO and the CoolSNAP KINO CCD cameras are designed to discern finer details in biological samples under lower light levels and enable scientists to achieve higher quality, higher resolution images than previous CCD technology. Packing twice as many pixels (2.8 megapixels) with a 15% improvement in peak quantum efficiency (75%), the MYO and KINO offer scientists the ability to visualize much finer details at much higher sensitivity than standard scientific CCD sensor technology. The MYO is capable of cooling to 0°and features a fan that can be disabled, which provides flexibility to optimize cooling for longer exposures in low-light scenarios and still accommodate extremely vibration-sensitive measurements. The KINO is cooled to 20°without a fan, making it suitable for sensitive applications such as AFM. The MYO and KINO are ideal camera technologies for immunofluorescence and fluorescent protein imaging, and also well suited for near-infrared DIC, electrophysiology, particle tracking, FRET, and FRAP imaging.


The PXi is a new high-resolution, multiapplication image analysis system. This powerful system is currently the best in its class for scientists who want a compact, one-click method for accurately imaging chemiluminescent and fluorescent blots as well as 1-D gels (up to 10 cm x 12 cm) stained with any type of fluorescent dye. The innovatively designed compact PXi, with its high-resolution 6.3 megapixel camera and large fixed aperture lens can quickly image even the faintest bands. It is easy to fit a range of lighting including infrared (IR) lighting and filter options inside the PXi system and using the intuitive GeneSys imaging software, the PXi can be rapidly set up to automatically select the best conditions. With just one-click, scientists can generate perfect images of chemiluminescent blots as well as 1-D gels (up to 10 cm x 12 cm) stained with any fluorescence and IR commercial dyes time after time.


The Combipack is an economic response to the growing use of protein precipitation separation techniques in chromatography labs. Comprising four Porvair p3 protein precipitation plates and four 1 mL deep well collection plates, the Combipack provides all the elements for protein precipitation separation, at a very affordable price. Based upon the industry standard MicroLute 96-well format, the p3 plate uses the CRASH method in which proteins are denatured with acetonitrile and the flocculent is filtered out. A novel dual filter matrix retains the samples in the wells of the p3 plate until required to release by vacuum or pressure. The use of a prefilter on top of an oleophobic filter eliminates blockages commonly found with other protein precipitation plates especially when handling high protein samples. The p3 has been proven in independent tests to eliminate the mess and complex sample preparation (no centrifuging, no vortexing) traditionally associated with protein


The Dimension FastScan Bio Atomic Force Microscope (AFM) enables high-resolution microscopy research in biological dynamics. Breakthrough innovations in the design of the FastScan Bio system have resulted in a fast scanning AFM that allows temporal investigation under physiological operating environments in fluid while exceeding the diffraction limits of optical microscopy. The Dimension FastScan Bio system utilizes a revolutionary XYZ scanner designed to operate at high-speed rates while delivering extremely low drift and low noise, along with a small volume fluid sample cell and a user interface that removes operational complexity. Other features include an industry-proven fast scanner, automated laser and detector alignment, an easy sample engaging process, and the capability to investigate samples in a droplet of solution or its 60 μL sample cell. With the FastScan Bio, productive spatiotemporal nanometer scale research is a reality for every bio researcher.


Whatman FF High Performance (HP) membranes are a new diagnostic membrane that enables fast, razor-sharp line separation and highly reproducible results for the detection of target molecules in liquids such as water, urine, blood, and saliva. The target molecules may include drugs, hormones, proteins, antibodies, nucleic acids, whole bacteria, and viruses. The FF HP membrane is suitable for use in lateral flow assay manufacture as it provides improved reliability and rapid results. The new membrane is produced using an innovative casting method to yield a uniform, new powder-free surface that delivers a coefficient of variation in capillary rise of <10%. Both the intra- and inter-lot consistency of the new membrane was tested through analysis of over 1,000 samples giving a low coefficient of variation. Three FF HP membranes are available with different capillary rise times (wicking rate); allowing researchers to choose the most suitable membrane for their assay.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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