PerspectiveNeuroscience

The Emerging Biology of Autism Spectrum Disorders

Science  14 Sep 2012:
Vol. 337, Issue 6100, pp. 1301-1303
DOI: 10.1126/science.1224989

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Summary

Autism spectrum disorders (ASD) are a genetically and phenotypically heterogeneous group of syndromes defined by fundamental impairments in social reciprocity and language development accompanied by highly restrictive interests and/or repetitive behaviors. Recent advances in genetics, genomics, developmental neurobiology, systems biology, monogenic neurodevelopment syndromes, and induced pluripotent stem cells (iPSC) are now offering remarkable insights into their etiologies and converging to provide a clear and immediate path forward from the bench to the bedside.