Wondering How the Wonder Drug Works

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Science  21 Sep 2012:
Vol. 337, Issue 6101, pp. 1472
DOI: 10.1126/science.337.6101.1472

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How does taking aspirin ward off cancer? Researchers still don't understand the mechanism, a lack of knowledge that threatens to frustrate development of better cancer prevention agents. But some say the latest clinical studies linking low-dose aspirin use with less cancer (see main text) suggest there's no need to improve upon this 113-year-old workhorse drug.