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Comment on “The Geometric Structure of the Brain Fiber Pathways”

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Science  28 Sep 2012:
Vol. 337, Issue 6102, pp. 1605
DOI: 10.1126/science.1223425

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Wedeen et al. (Reports, 30 March 2012, p. 1628) proposed a geometrical grid pattern in the brain that could help the understanding of the brain’s organization and connectivity. We show that whole-brain fiber crossing quantification does not support their theory. Our results suggest that the grid pattern is most likely an artifact attributable to the limitations of their method.

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