Technical Comments

Response to Comment on “The Geometric Structure of the Brain Fiber Pathways”

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Science  28 Sep 2012:
Vol. 337, Issue 6102, pp. 1605
DOI: 10.1126/science.1223493

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In response to Catani et al., we show that corticospinal pathways adhere via sharp turns to two local grid orientations; that our studies have three times the diffusion resolution of those compared; and that the noted technical concerns, including crossing angles, do not challenge the evidence of mathematically specific geometric structure. Thus, the geometric thesis gives the best account of the available evidence.

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