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Network Resets in Medial Prefrontal Cortex Mark the Onset of Behavioral Uncertainty

Science  05 Oct 2012:
Vol. 338, Issue 6103, pp. 135-139
DOI: 10.1126/science.1226518

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Changing Your Belief

The ability to display behavioral flexibility depends on an internal representation of the environment—a framework of beliefs that can be adjusted on the basis of experience. Recording from multiple electrodes in the rat medial prefrontal cortex, Karlsson et al. (p. 135) investigated how ensembles of neurons changed their activity during the performance of a task in which the animal had to update its knowledge of reward contingencies. The results suggest that changes in perceived action-outcome contingencies were associated with abrupt switches in neuronal representations in the rat medial prefrontal cortex.

Abstract

Regions within the prefrontal cortex are thought to process beliefs about the world, but little is known about the circuit dynamics underlying the formation and modification of these beliefs. Using a task that permits dissociation between the activity encoding an animal’s internal state and that encoding aspects of behavior, we found that transient increases in the volatility of activity in the rat medial prefrontal cortex accompany periods when an animal’s belief is modified after an environmental change. Activity across the majority of sampled neurons underwent marked, abrupt, and coordinated changes when prior belief was abandoned in favor of exploration of alternative strategies. These dynamics reflect network switches to a state of instability, which diminishes over the period of exploration as new stable representations are formed.

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