News & AnalysisChemistry

'Awesome' Synthesis Could Boost Protein-Based Drugs

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Science  05 Oct 2012:
Vol. 338, Issue 6103, pp. 28
DOI: 10.1126/science.338.6103.28

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Synthetic chemists have scaled a peak that offers a good view of not only their latest molecular target—a protein known as erythropoietin (EPO)—but a host of other molecular landmarks as well. Last week, researchers reported online in Angewandte Chemie that for the first time they had synthesized EPO with a uniform coating of sugar chains that decorate the outside of the natural molecule.