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Science  19 Oct 2012:
Vol. 338, Issue 6105, pp. 401
DOI: 10.1126/science.338.6105.401-a


The Scienceware Colony Counter provides a cost effective and accurate way to count colonies of bacteria or other microorganisms grown on an agar plate. The Scienceware Colony Counter is a simple-to-operate device that marks, counts, and gives an audible and visual alert each time a count is registered on the digital display. The lightweight, comfortable to hold, pen-style design reduces the likelihood of error, combining all aspects of counting into one motion. Error is further reduced by the ability to count both up and down to verify sample counts. Able to store up to 35 sample counts in its memory, the Colony Counter can also display the sum total of all colonies counted. The display has a backlight for easy viewing in low light conditions; the audible alert can be turned off if desired; and the counting function can be locked to prevent error during breaks between counting.


The BD MAX ExK DNA-1, ExK DNA-2, and ExK DNA-3 open system extraction kits as well as the BD MAX DNA MMK (SPC) and BD MAX DNA MMK open system master mix kits, for use on the BD MAX System, are designed to be used together to standardize testing, offer ease of use, and improve laboratory workflow. Optimized for specific sample types, the BD MAX open system extraction kits enable laboratories to standardize and automate user defined protocols. The reagent strips included in the BD MAX ExK DNA-1, ExK DNA-2, and ExK DNA-3 kits are designed to extract DNA from serum/plasma, cerebrospinal fluid/dry swabs, and swabs in universal transport medium/urine, respectively. The BD MAX DNA MMK (SPC) kit contains master mix tubes with the primers and probes to detect the sample processing control from the extraction reagents, while the BD MAX DNA MMK kit does not include these primers and probes.


The qBiomarker Copy Number PCR system measures changes in gene copy number with superior resolution and reliability compared to traditional methods. With the largest catalog of real-time polymerase chain reaction (PCR) assays available for copy number studies, researchers can choose from over 10 million assays—each designed with a sophisticated algorithm, and extensively wet-bench verified—to analyze changes in copy number at a resolution of 200 base pairs. The assays are available preprinted in PCR-ready arrays, with extensive catalogued content or user-defined custom content. These custom arrays are a great tool for verifying array-comparative genomic hybridization (aCGH) or single nucleotide polymorphism (SNP)-chip discovery experiments. The qBiomarker Copy Number PCR system leverages a cutting-edge multicopy reference assay for superior DNA input normalization, as compared with single-gene assays such as RNase P. Taken together, these features make the qBiomarker Copy Number PCR System one of the most advanced copy number qPCR systems available to the genotyping community.


Ni Sepharose Excel is an immobilized metal ion affinity chromatography (IMAC) medium (resin) for the direct capture and purification of secreted histidine-tagged recombinant proteins from eukaryotic cell culture supernatants. This new resin significantly reduces sample handling prior to purification and therefore increases target protein yield and decreases degradation. Ni Sepharose Excel is precharged with nickel ions that are very strongly bound to a chelating ligand and is designed primarily for the purification of histidine-tagged proteins secreted from eukaryotic cell-based expression systems. This resin is highly resistant to metal ion stripping and supports direct loading of large sample volumes, thus eliminating the need for time-consuming pretreatment procedures. It is also available as His Mag Sepharose Excel, which allows rapid capture by magnetic devices while also binding histidine-tagged proteins. This resin is ideally suited to small-scale experiments.


The new CytoSure ISCA +SNP (4×80k) array combines array comparative genomic hybridization (aCGH) probes, endorsed by the International Standards for Cytogenomic Arrays (ISCA) Consortium, with fully validated single nucleotide polymorphism (SNP) content. This allows the accurate and cost-effective detection of copy number changes and loss of heterozygosity (LOH) using a single array. The CytoSure ISCA +SNP array includes enhanced SNP coverage for high-resolution LOH detection. Although aCGH is the gold standard for detecting copy number variation (CNV), until recently it was not possible to combine this technique with LOH and uniparental disomy (UPD) detection using SNP probes. This meant that either two separate arrays were needed, or that inferior SNP-based CNV detection platforms were used. To solve this problem, the CytoSure ISCA +SNP array allows CNV and SNP detection to be carried out on a single array, using optimized probes that are fit for each purpose.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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