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Regulatory T Cells Increase the Avidity of Primary CD8+ T Cell Responses and Promote Memory

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Science  26 Oct 2012:
Vol. 338, Issue 6106, pp. 532-536
DOI: 10.1126/science.1227049

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Abstract

Although regulatory T cells (Tregs) are known to suppress self-reactive autoimmune responses, their role during T cell responses to nonself antigens is not well understood. We show that Tregs play a critical role during the priming of immune responses in mice. Treg depletion induced the activation and expansion of a population of low-avidity CD8+ T cells because of overproduction of CCL-3/4/5 chemokines, which stabilized the interactions between antigen-presenting dendritic cells and low-avidity T cells. In the absence of Tregs, the avidity of the primary immune response was impaired, which resulted in reduced memory to Listeria monocytogenes. These results suggest that Tregs are important regulators of the homeostasis of CD8+ T cell priming and play a critical role in the induction of high-avidity primary responses and effective memory.

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