PerspectiveImmunology

A Decorated Virus Cannot Hide

Science  09 Nov 2012:
Vol. 338, Issue 6108, pp. 748-749
DOI: 10.1126/science.1230342

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Summary

The coagulation system protects our bodies from excessive loss of blood from a leaky or damaged vessel, whereas the immune system protects us from invading pathogens such as viruses. Unexpected links between these two systems suggest their coevolution (1, 2). On page 795 in this issue, Doronin et al. show that an essential protein for the clotting process binds to a virus that has entered the blood stream, thereby allowing the immune system to sense the invader and mount a rapid and potent antiviral response (3).