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Science  16 Nov 2012:
Vol. 338, Issue 6109, pp. 981
DOI: 10.1126/science.338.6109.981-a


The ORION NanoFab is the first multi-ion-beam tool based on Gas Field Ion Source (GFIS) technology. As a major enhancement to the existing helium ion microscope, ORION NanoFab also utilizes neon ions. The system is therefore capable of providing a complete sub-10 nanometer nanofabrication and sub-nanometer imaging solution for industry, government, and academic research laboratories. An optional gallium focused ion beam (FIB) column can also be integrated. The neon ion beam offers precise machining and nanofabrication capabilities due to higher sputter yields in ion beam milling and faster resist exposure in ion beam lithography. The helium ion beam allows sub-10 nm nanofabrication as well as high resolution imaging capability in the same instrument. The optional state-of-the-art gallium FIB column allows massive material removal. This makes ORION NanoFab the most versatile nanofabrication and imaging platform available.


XGen Lockdown Probes are individually synthesized 60–120 nucleotide 5'-biotinylated capture oligonucleotides designed to enable cost-effective, high-depth sequencing, and analysis of specific regions of the genome. xGen Lockdown Probes are ideal for target enrichment and custom panel development, and capture sets can be easily expanded. Available at three different scales (mini – 2 pmole, standard – 20 pmole, and XL – 200 pmole), users can design their initial capture panels using the mini scale and extend them by progressively supplementing with more probes. Whether used with custom capture panels, or for supplementing existing panels, xGen Lockdown Probes provide approximately 5,000-fold enrichment with high coverage over targeted regions, and minimal GC bias. Furthermore, the probes can be added to array-derived RNA baits to enhance coverage of GC-rich targets, such as first exons. Users can therefore improve capture performance by rescuing drop-out regions of array-derived exome capture, improve the uniformity of coverage, discover additional genetic mutations, or improve coverage of specific regions of interest without redesigning a new panel.


The TC20 automated cell counter is the next generation of the TC10 automated cell counter which provides accurate and reliable counts of live mammalian cells in 30 seconds. The TC20 system's improved lens and cell counting algorithm make it compatible with a broader range of cell sizes and types. This includes cells smaller than 10 μm and complex samples such as stem cells and primary cells derived from tissue or blood. Many of the advanced features of the TC10 system, such as the auto-focus technology that provides highly reproducible cell counts with reduced user-to-user variability, remain in the TC20 system. The TC20 also has the ability to analyze cells across multiple focal planes, which eliminates live cell undercounting associated with single focal plane analysis. And unlike electrical impedance-based counters, researchers can view cells in real time to immediately confirm their total and live/dead cell counts.


A new suite of cell adhesion assays have been designed to evaluate optimal cell attachment to extracellular matrices and assess factors that influence cell-matrix interactions. CultreCoat Cell Adhesion Assays are precoated and ready-to-use in a black stripwell microplate format that minimizes background, allows greater sensitivity, and affords flexibility in the number of samples assessed. The stripwell feature also allows multiple experiments to be conducted simultaneously using the same kit. Calcein labeling allows direct comparisons between the number of cells that are loaded and the number that adhere. Controls are provided for determining background and nonspecific binding. The new adhesion protein array kit enables researchers, on a single microplate, to assess adhesion on Basement Membrane Extract (equivalent to Matrigel), Laminin, Collagen I, Collagen IV, Fibronectin, and Vitronectin.


The Microlute solid-phase extraction (SPE) sample preparation system provides a faster, trouble-free alternative to cartridges for high throughput sample cleanup. Handling samples as small as 150 uL, the Microlute SPE sample preparation system helps increase assay sensitivity by providing preinjection cleanup and concentration. As a complete package, including filter plate, collection plate, waste tray and manifold, the Microlute SPE sample preparation system offers all the advantages of automated and high throughput SPE sample preparation in a convenient microplate format capable of rapidly processing 96 samples in one go repeatedly and precisely. Using a proprietary sorbent slurry loading technique, Porvair has eliminated the channeling effects that often limit the performance of dry powder loaded SPE columns. Each well on a Microlute plate has an individual drain spout ensuring 100% sample transfer and zero crossover contamination. To recover dried or concentrated sample the Microlute SPE sample preparation system may be coupled to a Porvair MiniVap sample concentrator.

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