The Runners-Up

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Science  21 Dec 2012:
Vol. 338, Issue 6114, pp. 1525-1532
DOI: 10.1126/science.338.6114.1525

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This year's runners-up for Breakthrough of the Year include a remarkable new method to prepare single strands of ancient DNA and view their genomes, transcription activator–like effector nucleases that can destroy or alter specific genes, neutrino physics, the Encyclopedia of DNA Elements, the flawless performance of the Mars Curiosity rover, the first time an x-ray laser was used to determine the structure of a protein, the use of a brain-machine interface by paralyzed human patients to execute complex movements, Majorana fermions, and the production of eggs cells from stem cells.