PerspectiveBiochemistry

Visualizing the Influenza Genome

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Science  21 Dec 2012:
Vol. 338, Issue 6114, pp. 1545-1546
DOI: 10.1126/science.1231588

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Summary

Cellular organisms have evolved complex mechanisms to maintain and regulate genome structure and dynamics. Viruses are no exception. On pages 1634 and 1631 of this issue, Arranz et al. (1) and Moeller et al. (2) report three-dimensional views of the genomic RNA-protein complex of the influenza A virus, the infamous pathogen responsible for human flu epidemics and pandemics. These findings should help to elevate our understanding of influenza virus structure and biology to a new level.