PerspectiveBiochemistry

How to Solve Protein Structures with an X-ray Laser

Science  11 Jan 2013:
Vol. 339, Issue 6116, pp. 146-147
DOI: 10.1126/science.1233209

You are currently viewing the summary.

View Full Text

Summary

For over a decade, biologists have asked whether x-ray lasers can be used to determine the structures of biomolecules such as proteins. Such methods have the potential to allow structure determination from micro- or even nanoscale crystals, but radiation damage can be extensive and data interpretation is fraught with difficulty. On page 227 of this issue, Redecke et al. (1) overcome these problems to determine the room-temperature structure of a protein of importance to drug discovery.