New Products

Science  25 Jan 2013:
Vol. 339, Issue 6118, pp. 468
DOI: 10.1126/science.339.6118.468-a

TRANSILLUMINATOR

The advanced Bi-O-Vision Series transilluminators feature two workstations, producing both 312 nm ultraviolet (UV) and white light. The TD-1000R model offers fixed-intensity while the TVD-1000R model offers variable-intensity control of either UV or white light. These units are continuously adjustable from 100% down to 50%. This enables life science researchers to select the exact ultraviolet or white light illumination needed to photodocument samples with a single piece of equipment. The UV-B (312 nm) intensity of the TVD-1000R can be varied. This flexibility in irradiance control helps ensure the longest sample preparation time, while minimizing actual UV damage to the sample. The Bi-O-Vision has two adjacent workstations, each with a filter area of 8 x 8" (20 x 20 cm). The UV side is lit by five 8-watt UV-B tubes and delivers nanogram sensitivity for detecting ethidium bromide-stained DNA or RNA. The white light side has three 8-watt fluorescent tubes that ensure excellent illumination for viewing Coomassie blue-stained protein gels, methylene blue-stained DNA gels, and autoradiograms.

FFPET SAMPLE PREP

The new High Pure FFPET RNA Isolation Kit and the RealTime ready cDNA Pre-Amp Master & Primer Pools have been designed for gene expression analysis of formalin-fixed, paraffin-embedded tissue (FFPET) samples. FFPET samples from biopsies or microdissections are frequently used for retrospective studies. They also represent an increasingly important resource for biomarker research and investigating disease progression or drug responsiveness. The new High Pure FFPET RNA Isolation Kit delivers RNA of excellent integrity and yield—two key factors in ensuring high-quality results in the diversity of downstream applications such as qRT polymerase chain reaction, microarray analysis, and sequencing. For comprehensive gene expression studies, the isolated RNA can be transcribed into cDNA and subsequently pre-amplified with the new RealTime ready cDNA Pre-Amp Master. This kit makes it possible to preamplify minute amounts of cDNA with customized primer pools that correspond perfectly to the primers which can be applied in subsequent qPCR analysis.

SAMPLE PREPARATION

The Genevac Flip-Flop system is an innovative tool designed to facilitate post-accelerated sample extraction (ASE) concentration and preparation of samples. Samples are collected in the special Flip-Flop tube, the funnel and vial are fitted, the tube flipped over and second cap removed. Your ASE sample can now be concentrated directly into a GC autosampler vial using a Genevac Rocket Evaporator. The Genevac Rocket Evaporator enables rapid concentration or evaporation of up to 18 Dionex ASE vials simultaneously. Using this simple procedure eliminates manual transfer steps and helps automate the ASE sample concentration/preparation process resulting in improved laboratory workflow, increased reproducibility of results, and enhanced sample recovery.

EXTRACELLULAR MATRIX COMBINATORIAL LIBRARY

Containing nearly 300 biomimetics of fibronectin, vitronectin, laminin, and collagen for coating plates or creating 3-D culture scaffolds, the new Extracellular Matrix (ECM) Mimetic Library provides a powerful tool for identifying the cellular adhesion profile of cell lines or tumors against the widest commercially available collection of cell surface receptor binding peptide motifs. The extracellular microenvironment, defined by biochemical and physical cues, is a deciding factor in a wide range of cellular processes, including cell adhesion, proliferation, differentiation, and expression of phenotype-specific functions. Being able to engineer the ECM microenvironment provides clear benefits in studies of cell and tissue engineering and related applications. Currently existing technology offers simple (and merely adequate) environments that facilitate basic cell processes such as adhesion. The simple presentation of motifs involved in cell adhesion is not optimal for controlling more integrated processes. Crosstalk among signaling pathways acts synergistically to enhance cellular responses such as cell adhesion and/or proliferation.

WNT REPORTER ASSAY

The Leading Light Wnt Reporter Assay is a high-sensitivity system that accelerates screening analysis of Wnt pathway modulators. The Leading Light Wnt Reporter Assay guarantees confidence in the assay results by providing a system that is capable of detecting low concentration of effectors across a dynamic range of signal intensity. The assay uses a 3T3 mouse fibroblast cell line modified with a luciferase reporter gene under the control of Wnt-responsive promoters (TCF/LEF). It provides a true endpoint detection system for screening compounds without the need for overexpression or alteration of pathway signaling molecules. With a chemiluminescent readout amenable to both 96-well and 384-well plate formats, the kit allows for high throughput analysis of Wnt pathway activators and inhibitors. The Leading Light Wnt Reporter Assay Starter Kit is supplied with an easy-to-follow protocol, a validated cell line and all necessary media, reagents, and controls.

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  • Newly offered instrumentation, apparatus, and laboratory materials of interest to researchers in all disciplines in academic, industrial, and governmental organizations are featured in this space. Emphasis is given to purpose, chief characteristics, and availabilty of products and materials. Endorsement by Science or AAAS of any products or materials mentioned is not implied. Additional information may be obtained from the manufacturer or supplier.

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