Faulty DNA Repair Linked to Ovarian Aging in Mice and Humans

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Science  15 Feb 2013:
Vol. 339, Issue 6121, pp. 749
DOI: 10.1126/science.339.6121.749

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A woman's cache of eggs drops precipitously right around her 37th birthday, but the reasons have always been puzzling. Researchers are converging on one new and eminently logical answer: The ovary's ability to repair damaged DNA may decline over time, and with it, the survival of its eggs. A new study of mice and humans whose natural ability to fix DNA is impaired, published this week in Science Translational Medicine, bolsters this theory.